CONFIDENTIAL
CLINICIAN'S OVERVIEW
Sleep
Report: Sleep
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Circadian Rhythms
Genes involved:
BDNF, CLOCK, COMT, DRD2, ADRA2B, CYP2R1, GC, VDR
RESULT + SUMMARY

This patient carries the normal or optimal profile
SUPPLEMENT
RECOMMENDATIONS

No Recommendation
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

No Recommendation
Report: Sleep
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Stress Response
Genes involved:
COMT, DRD2, 5HTTLPR, TPH2, ADRA2B, BDNF
RESULT + SUMMARY

This patient is at an increased risk of chronic poor sleep due to a suboptimal stress response. Stressors from work, family, or personal issues are more likely to disrupt their ability to fall and stay asleep.
SUPPLEMENT
RECOMMENDATIONS

Magnesium Bisglycinate
L-theanine
Deep Calm Optimizer
Adaptogens: Ashwagandha, Tulsi, Rhodiola, Lavender
Omega 3
Blood sugar regulation (chromium, ALA, low dose berberine)
Vitamin B12 (see methylation genes)
5-HTP
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Explore breathing techniques to use as needed.
Prioritize relaxing activities each evening.
Avoid stimulants like caffeine, especially after 2pm.
Report: Sleep
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Pleasure Response
Genes involved:
COMT, MAO, DRD2
RESULT + SUMMARY

This patient is at an increased risk of chronic poor sleep due to a heightened pleasure response. Addictive or binge habits related to food, technology, or abused substances are more likely to disrupt their ability to fall asleep at an appropriate time. They are more likely to forego proper sleep in favour of their pleasurable activity of choice
SUPPLEMENT
RECOMMENDATIONS

-
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Stop binge-watching shows, especially after dark.
Seek out pleasurable activities that benefit your sleep quality instead of compromising it.
Report: Sleep
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Food Response
Genes involved:
FTO, MC4R, COMT, DRD2, MAO
RESULT + SUMMARY

This patient is at an increased risk of disrupted sleep patterns due to a heightened food response. They are more likely to engage in irregular snacking behaviors, particularly in the evening. This may disrupt their ability to fall asleep or stay asleep.
SUPPLEMENT
RECOMMENDATIONS

Youtrients Blood Sugar Regulator
Alpha Lipoic Acid (ALA)
Chromium
Berberine
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Stop eating 2-3 hours before bed.
When snacking, prepare snack foods that offer a combination of beneficial nutrients.
Have a warm cup of tea instead of food as a "snack" before bed.
Report: Sleep
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Environmental Response
Genes involved:
GSTT1, GSTM1, GSTP1, SOD2, GPX
RESULT + SUMMARY

This patient is at an increased risk of chronic poor sleep due to a suboptimal environmental response. External toxins like mold, pollution, smoking, and other environmental agents are more likely to linger in this patient.
Similarly, internal toxins like oxidants are more likely to cause cellular oxidative stress. These factors can contribute to increased symptomatology related to fatigue, tiredness and lack of energy.
SUPPLEMENT
RECOMMENDATIONS

Youtrients Detox Optimizer
NAC
Milk Thistle
Selenium
Manganese
Alpha Lipoic Acid
Vitamin C
Magnesium
Sulforaphane
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Use an air filter in the bedroom.
Vacuum and clean dust regularly in the home.
Minimize the use of chemicals at home by purchasing green or environmentally friendly household cleaning products.
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Sleep
GENE

GSTT1
CNV
(# of copies)
GENOTYPE + DESCRIPTION

2
Associated with increased enzyme function and clearance of substrates with increased ability to detoxify environmental xenobiotics, pharmaceutics and ROS
1
Associated with average enzyme function and clearance of substrates with average ability to detoxify environmental xenobiotics, pharmaceutics and ROS
0
Associated with no enzyme production and poorer clearance of substrates with decreased ability to detoxify environmental xenobiotics, pharmaceutics and ROS

GENE

GSTM1
CNV
(# of copies)
GENOTYPE + DESCRIPTION

2
Associated with increased enzyme function and clearance of substrates with increased ability to detoxify environmental xenobiotics, pharmaceutics and ROS
1
Associated with average enzyme function and clearance of substrates with average ability to detoxify environmental xenobiotics, pharmaceutics and ROS
0
Associated with no enzyme production and poorer clearance of substrates with decreased ability to detoxify environmental xenobiotics, pharmaceutics and ROS
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Sleep
GENE

GSTP1
rs1695
GENOTYPE + DESCRIPTION

AA
Associated with optimal enzyme function and optimal clearance of substrates and reactive oxygen species
AG
Associated with sub-optimal enzyme function and suboptimal clearance of substrates and reactive oxygen species
GG
Associated with sub-optimal enzyme function and suboptimal clearance of substrates and reactive oxygen species

GENE

SOD2
rs4880
GENOTYPE + DESCRIPTION

CC
Associated with optimal catalytic activity and optimal clearance of free radicals within the mitochondria
CT
Associated with 30 to 40 percent reduction in catalytic activity, with increased susceptibility to oxidative stress within the mitochondria
TT
Associated with suboptimal catalytic activity (70 percent reduction) with increased susceptibility to oxidative stress within the mitochondria
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Sleep
GENE

GPX
rs1050450
GENOTYPE + DESCRIPTION

CC
Associated with faster conversion of hydrogen peroxide created from oxidant metabolism via SOD2 into water and diatomic oxygen
CT
Associated with medium conversion of hydrogen peroxide created from oxidant metabolism via SOD2 into water and diatomic oxygen
TT
Associated with slower conversion of hydrogen peroxide created from oxidant metabolism via SOD2 into water and diatomic oxygen

GENE

CYP2R1
Rs10741657
GENOTYPE + DESCRIPTION

AA
Associated with optimal activation of vitamin D and optimal levels of circulating vitamin D
AG
Associated with suboptimal activation of vitamin D and suboptimal levels of circulating vitamin D
GG
Associated with suboptimal activation of vitamin D and suboptimal levels of circulating vitamin D
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Sleep
GENE

GC/VDBP
Rs4588
GENOTYPE + DESCRIPTION

CC
Associated with optimal levels of vitamin D
AC
Associated with suboptimal levels of vitamin D
AA
Associated with suboptimal levels of vitamin D

GENE

VDR
rs1544410
GENOTYPE + DESCRIPTION

CC
Associated with optimal vitamin D receptor activation and binding
CT
Associated with suboptimal vitamin D receptor activation and binding
TT
Associated with suboptimal vitamin D receptor activation and binding
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Sleep
GENE

BDNF
rs6265
GENOTYPE + DESCRIPTION

AA
Associated with suboptimal production and levels of brain-derived neurotrophic factor
AG
Associated with suboptimal production and levels of brain-derived neurotrophic factor
GG
Associated with optimal production and levels of brain-derived neurotrophic factor*

GENE

CLOCK
rs1801260
GENOTYPE + DESCRIPTION

TT
Associated with normal sleep and waking patterns
CT
Associated with delayed or reduced sleep and waking patterns
CC
Associated with delayed or reduced sleep and waking patterns
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Sleep
GENE

COMT
Rs4680
GENOTYPE + DESCRIPTION

AA
Associated with lowest COMT activity and longest dopamine half-life
AG
Associated with moderate COMT activity and medial dopamine half-life
GG
Associated with highest COMT activity and shortest dopamine half-life

GENE

MAO
Rs6323
GENOTYPE + DESCRIPTION

TT
Associated with lowest MAO activity and longest dopamine half-life
GT
Associated with moderate MAO activity and medial dopamine half-life
GG
Associated with highest MAO activity and shortest dopamine half-life
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Sleep
GENE

DRD2
Rs1800497
GENOTYPE + DESCRIPTION

AA
Associated with lowest expression of post-synaptic DRD2 receptors with lowest dopamine binding, post-synaptic activation and pleasure response
AG
Associated with moderate expression of post-synaptic neuronal DRD2 receptors with moderate dopamine binding, post-synaptic activation and pleasure response
GG
Associated with highest expression of post-synaptic neuronal DRD2 receptors with moderate dopamine binding, post-synaptic activation and pleasure response

GENE

ADRA2B
INDEL
GENOTYPE + DESCRIPTION

II
Associated with normal desensitization of noradrenergic receptors, resulting in reduced/balanced memory of negative emotional events
ID
Associated with decreased desensitization of noradrenergic receptors, resulting in enhanced memory of negative emotional events (potentially poor responder to SNRIs)
DD
Associated with decreased desensitization of noradrenergic receptors, resulting in enhanced memory of negative emotional events (potentially poor responder to SNRIs)
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Sleep
GENE

5HTTLPR
INDEL
GENOTYPE + DESCRIPTION

LL
Associated with optimal expression of the serotonin transporter with optimal serotonin secretion and re-uptake
LS
Associated with decreased expression of the serotonin transporter with dysregulated serotonin secretion and re-uptake (potentially poor responder to SSRIs)
SS
Associated with decreased expression of the serotonin transporter with dysregulated serotonin secretion and re-uptake (potentially poor responder to SSRIs)

GENE

FTO
rs9939609
GENOTYPE + DESCRIPTION

TT
Associated with normal postprandial satiety with reduced risk of obesity in healthy individuals
AT
Associated with moderate postprandial satiety with moderate risk of obesity
AA
Associated with low postprandial satiety with increased risk of obesity
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Sleep
GENE

MC4R
rs17782313
GENOTYPE + DESCRIPTION

TT
Associated with normative hunger cues and reduced snacking behaviour
CT
Associated with dysregulated hunger cues and increased snacking behaviour
CC
Associated with dysregulated hunger cues and increased snacking behaviour

GENE

GENOTYPE + DESCRIPTION