This patient carries the normal or optimal profile
SUPPLEMENT
RECOMMENDATIONS
No Recommendation
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS
No Recommendation
THE
DNA
COMPANY
2
Report:
Sleep
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
HEALTH CONCERN
Stress Response
Genes involved:
COMT, DRD2, 5HTTLPR, TPH2, ADRA2B, BDNF
RESULT + SUMMARY
This patient is at an increased risk of chronic poor sleep due to a suboptimal stress response. Stressors from work, family, or personal issues are more likely to disrupt their ability to fall and stay asleep.
SUPPLEMENT
RECOMMENDATIONS
Magnesium Bisglycinate L-theanine Deep Calm Optimizer Adaptogens: Ashwagandha, Tulsi, Rhodiola, Lavender Omega 3 Blood sugar regulation (chromium, ALA, low dose berberine) Vitamin B12 (see methylation genes) 5-HTP
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS
Explore breathing techniques to use as needed. Prioritize relaxing activities each evening. Avoid stimulants like caffeine, especially after 2pm.
THE
DNA
COMPANY
3
Report:
Sleep
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
HEALTH CONCERN
Pleasure Response
Genes involved:
COMT, MAO, DRD2
RESULT + SUMMARY
This patient is at an increased risk of chronic poor sleep due to a heightened pleasure response. Addictive or binge habits related to food, technology, or abused substances are more likely to disrupt their ability to fall asleep at an appropriate time. They are more likely to forego proper sleep in favour of their pleasurable activity of choice
SUPPLEMENT
RECOMMENDATIONS
-
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS
Stop binge-watching shows, especially after dark. Seek out pleasurable activities that benefit your sleep quality instead of compromising it.
THE
DNA
COMPANY
4
Report:
Sleep
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
HEALTH CONCERN
Food Response
Genes involved:
FTO, MC4R, COMT, DRD2, MAO
RESULT + SUMMARY
This patient is at an increased risk of disrupted sleep patterns due to a heightened food response. They are more likely to engage in irregular snacking behaviors, particularly in the evening. This may disrupt their ability to fall asleep or stay asleep.
Stop eating 2-3 hours before bed. When snacking, prepare snack foods that offer a combination of beneficial nutrients. Have a warm cup of tea instead of food as a "snack" before bed.
THE
DNA
COMPANY
5
Report:
Sleep
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
HEALTH CONCERN
Environmental Response
Genes involved:
GSTT1, GSTM1, GSTP1, SOD2, GPX
RESULT + SUMMARY
This patient is at an increased risk of chronic poor sleep due to a suboptimal environmental response. External toxins like mold, pollution, smoking, and other environmental agents are more likely to linger in this patient. Similarly, internal toxins like oxidants are more likely to cause cellular oxidative stress. These factors can contribute to increased symptomatology related to fatigue, tiredness and lack of energy.
Use an air filter in the bedroom. Vacuum and clean dust regularly in the home. Minimize the use of chemicals at home by purchasing green or environmentally friendly household cleaning products.
THE
DNA
COMPANY
6
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
Report:
Sleep
GENE
GSTT1 CNV (# of copies)
GENOTYPE + DESCRIPTION
2
Associated with increased enzyme function and clearance of substrates with increased ability to detoxify environmental xenobiotics, pharmaceutics and ROS
1
Associated with average enzyme function and clearance of substrates with average ability to detoxify environmental xenobiotics, pharmaceutics and ROS
0
Associated with no enzyme production and poorer clearance of substrates with decreased ability to detoxify environmental xenobiotics, pharmaceutics and ROS
GENE
GSTM1 CNV (# of copies)
GENOTYPE + DESCRIPTION
2
Associated with increased enzyme function and clearance of substrates with increased ability to detoxify environmental xenobiotics, pharmaceutics and ROS
1
Associated with average enzyme function and clearance of substrates with average ability to detoxify environmental xenobiotics, pharmaceutics and ROS
0
Associated with no enzyme production and poorer clearance of substrates with decreased ability to detoxify environmental xenobiotics, pharmaceutics and ROS
7
THE
DNA
COMPANY
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
Report:
Sleep
GENE
GSTP1 rs1695
GENOTYPE + DESCRIPTION
AA
Associated with optimal enzyme function and optimal clearance of substrates and reactive oxygen species
AG
Associated with sub-optimal enzyme function and suboptimal clearance of substrates and reactive oxygen species
GG
Associated with sub-optimal enzyme function and suboptimal clearance of substrates and reactive oxygen species
GENE
SOD2 rs4880
GENOTYPE + DESCRIPTION
CC
Associated with optimal catalytic activity and optimal clearance of free radicals within the mitochondria
CT
Associated with 30 to 40 percent reduction in catalytic activity, with increased susceptibility to oxidative stress within the mitochondria
TT
Associated with suboptimal catalytic activity (70 percent reduction) with increased susceptibility to oxidative stress within the mitochondria
8
THE
DNA
COMPANY
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
Report:
Sleep
GENE
GPX rs1050450
GENOTYPE + DESCRIPTION
CC
Associated with faster conversion of hydrogen peroxide created from oxidant metabolism via SOD2 into water and diatomic oxygen
CT
Associated with medium conversion of hydrogen peroxide created from oxidant metabolism via SOD2 into water and diatomic oxygen
TT
Associated with slower conversion of hydrogen peroxide created from oxidant metabolism via SOD2 into water and diatomic oxygen
GENE
CYP2R1 Rs10741657
GENOTYPE + DESCRIPTION
AA
Associated with optimal activation of vitamin D and optimal levels of circulating vitamin D
AG
Associated with suboptimal activation of vitamin D and suboptimal levels of circulating vitamin D
GG
Associated with suboptimal activation of vitamin D and suboptimal levels of circulating vitamin D
9
THE
DNA
COMPANY
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
Report:
Sleep
GENE
GC/VDBP Rs4588
GENOTYPE + DESCRIPTION
CC
Associated with optimal levels of vitamin D
AC
Associated with suboptimal levels of vitamin D
AA
Associated with suboptimal levels of vitamin D
GENE
VDR rs1544410
GENOTYPE + DESCRIPTION
CC
Associated with optimal vitamin D receptor activation and binding
CT
Associated with suboptimal vitamin D receptor activation and binding
TT
Associated with suboptimal vitamin D receptor activation and binding
10
THE
DNA
COMPANY
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
Report:
Sleep
GENE
BDNF rs6265
GENOTYPE + DESCRIPTION
AA
Associated with suboptimal production and levels of brain-derived neurotrophic factor
AG
Associated with suboptimal production and levels of brain-derived neurotrophic factor
GG
Associated with optimal production and levels of brain-derived neurotrophic factor*
GENE
CLOCK rs1801260
GENOTYPE + DESCRIPTION
TT
Associated with normal sleep and waking patterns
CT
Associated with delayed or reduced sleep and waking patterns
CC
Associated with delayed or reduced sleep and waking patterns
11
THE
DNA
COMPANY
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
Report:
Sleep
GENE
COMT Rs4680
GENOTYPE + DESCRIPTION
AA
Associated with lowest COMT activity and longest dopamine half-life
AG
Associated with moderate COMT activity and medial dopamine half-life
GG
Associated with highest COMT activity and shortest dopamine half-life
GENE
MAO Rs6323
GENOTYPE + DESCRIPTION
TT
Associated with lowest MAO activity and longest dopamine half-life
GT
Associated with moderate MAO activity and medial dopamine half-life
GG
Associated with highest MAO activity and shortest dopamine half-life
12
THE
DNA
COMPANY
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
Report:
Sleep
GENE
DRD2 Rs1800497
GENOTYPE + DESCRIPTION
AA
Associated with lowest expression of post-synaptic DRD2 receptors with lowest dopamine binding, post-synaptic activation and pleasure response
AG
Associated with moderate expression of post-synaptic neuronal DRD2 receptors with moderate dopamine binding, post-synaptic activation and pleasure response
GG
Associated with highest expression of post-synaptic neuronal DRD2 receptors with moderate dopamine binding, post-synaptic activation and pleasure response
GENE
ADRA2B INDEL
GENOTYPE + DESCRIPTION
II
Associated with normal desensitization of noradrenergic receptors, resulting in reduced/balanced memory of negative emotional events
ID
Associated with decreased desensitization of noradrenergic receptors, resulting in enhanced memory of negative emotional events (potentially poor responder to SNRIs)
DD
Associated with decreased desensitization of noradrenergic receptors, resulting in enhanced memory of negative emotional events (potentially poor responder to SNRIs)
13
THE
DNA
COMPANY
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
Report:
Sleep
GENE
5HTTLPR INDEL
GENOTYPE + DESCRIPTION
LL
Associated with optimal expression of the serotonin transporter with optimal serotonin secretion and re-uptake
LS
Associated with decreased expression of the serotonin transporter with dysregulated serotonin secretion and re-uptake (potentially poor responder to SSRIs)
SS
Associated with decreased expression of the serotonin transporter with dysregulated serotonin secretion and re-uptake (potentially poor responder to SSRIs)
GENE
FTO rs9939609
GENOTYPE + DESCRIPTION
TT
Associated with normal postprandial satiety with reduced risk of obesity in healthy individuals
AT
Associated with moderate postprandial satiety with moderate risk of obesity
AA
Associated with low postprandial satiety with increased risk of obesity
14
THE
DNA
COMPANY
Patient:
Kashif Khan- New test kit
Patient ID:
MG6644
Report:
Sleep
GENE
MC4R rs17782313
GENOTYPE + DESCRIPTION
TT
Associated with normative hunger cues and reduced snacking behaviour
CT
Associated with dysregulated hunger cues and increased snacking behaviour
CC
Associated with dysregulated hunger cues and increased snacking behaviour