CONFIDENTIAL
CLINICIAN'S OVERVIEW
Diet and Nutrition
Report: Diet and Nutrition
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Fat Metabolism
Genes involved:
APOA2, TCF7L2, ACE, FTO
RESULT + SUMMARY

This patient carries the normal or optimal profile
SUPPLEMENT
RECOMMENDATIONS

No Recommendation
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

No Recommendation
Report: Diet and Nutrition
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Carb Metabolism
Genes involved:
AMY1, FTO, TCF7L2
RESULT + SUMMARY

This patient has an increased association between starch consumption and weight gain. They are likely to gain weight on a diet with medium to high carb consumption.
Diets such as the paleolithic or adjusted versions of the mediterranean diet that involve low carbohydrate consumption should be considered.
SUPPLEMENT
RECOMMENDATIONS

Consider Digestive Enzyme for special occasions/carb heavy meals
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Find a mindfulness or meditation technique one enjoys and start practicing it for 5 minutes every morning.

Normalize anxiety - it is common, it can be managed.

Understand triggers (people, foods, situations) and create habits that either self-soothe during those moments or enable exit.

Recognize when referral is needed and have a list of appropriate resources ready.
Report: Diet and Nutrition
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Insulin Resistance
Genes involved:
TCF7L2, APOA2, AMY1
RESULT + SUMMARY

This patient has an increased risk of insulin resistance. If they carry a normal fat or starch metabolism profile, they should approach diets high in fats or carbs with caution, as these diets can significantly raise blood glucose levels.
This patient also carries an increased risk of Type II Diabetes. A calorie-restricted diet is the most ideal long-term diet for this profile.
SUPPLEMENT
RECOMMENDATIONS

The following is to support blood sugar regulation, be mindful of any blood sugar or insulin regulation medications, such as Metformin.
Youtrients Blood Sugar Regulator
Alpha Lipoic Acid (ALA)
Chromium
Berberine
Inositol (if indicated by hormone picture)
Potential candidate for proactive low-dose metformin therapy
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Reduce or eliminate added sugar in the diet.
Choose low-carb or no-carb food options late in the day.
When having a carb, choose those with a low glycemic load.
Report: Diet and Nutrition
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Gut Microbiome Health
Genes involved:
GSTT1, GSTM1, GSTP1, FUT2, CYP2R1, GC, VDR
RESULT + SUMMARY

No Recommendation
SUPPLEMENT
RECOMMENDATIONS

No Recommendation
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

No Recommendation
Report: Diet and Nutrition
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Lactose Tolerance
Genes involved:
MCM6
RESULT + SUMMARY

This patient carries a reduced tolerance to lactose-based products and is likely to display some form of symptoms associated with lactose intolerance.
SUPPLEMENT
RECOMMENDATIONS

Refer to diet and lifestyle references.
Lactase digestive enzyme, if your patient is consuming lactose
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Avoid all foods containing lactose.
Find dairy/lactose replacements that work well for you.
Report: Diet and Nutrition
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Gluten Sensitivity
Genes involved:
HLA GENES
RESULT + SUMMARY

This patient carries variations associated with non-Celiac gluten sensitivity.
SUPPLEMENT
RECOMMENDATIONS

9p21 (6G) counsel patients for gluten elimination for non-celiac gluten sensitivity.
For patients who have 9p21 0G to 2G, digestive enzyme are suitable as needed when eating foods with gluten.
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Minimize consumption of wheat-based products like pasta, breads, and sweets.
Choose gluten-free foods whenever possible,
Learn about alternative ways to prepare your favorite meals while omitting gluten.
Report: Diet and Nutrition
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Obesity Risk
Genes involved:
FTO, MC4R, COMT, 5HTTLPR, BDNF
RESULT + SUMMARY

This patient carries the normal or optimal profile
SUPPLEMENT
RECOMMENDATIONS

No Recommendation
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

No Recommendation
Report: Diet and Nutrition
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Binge Eating Risk
Genes involved:
COMT, DRD2, MC4R, FTO
RESULT + SUMMARY

This patient carries the normal or optimal profile
SUPPLEMENT
RECOMMENDATIONS

No Recommendation
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

No Recommendation
Report: Diet and Nutrition
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Vitamin A Conversion
Genes involved:
BCMO1
RESULT + SUMMARY

This patient carries a suboptimal Vitamin A profile. Their ability to convert beta-carotene into retinol is considered suboptimal. If this patient follows a vegan or plant based diet, they should be encouraged to source retinol-based vitamin A supplementation.
SUPPLEMENT
RECOMMENDATIONS

If the individual is suboptimal and on a vegetarian/vegan diet, consider retinol supplementation.
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

-
Report: Diet and Nutrition
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Vitamin C Transport
Genes involved:
SLC23A1
RESULT + SUMMARY

No Recommendation
SUPPLEMENT
RECOMMENDATIONS

No Recommendation
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

No Recommendation
Report: Diet and Nutrition
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Vitamin D Conversion, Transport, and Binding
Genes involved:
CYP2R1, GC, VDR
RESULT + SUMMARY

This patient is more likely to have suboptimal Vitamin D levels. The issue of suboptimality depends on which genes have suboptimal variations. poor CYP2R1 function means reduced conversion of Vitamin D from D2 to D3 (activated form).
Poor GC/VDBP function means reduced transport of Vitamin D from site of activation to site of function. Poor VDR function means reduced ability of Vitamin D to bind to its receptor and activate its functions in the body.
SUPPLEMENT
RECOMMENDATIONS

Serum D levels should be assessed before instituting therapy and afterwards to assess/monitor progress.
When vitamin D therapy is indicated, always use Vitamin D3.
Vitamin D supplementation should be offered during the day, ideally in the morning.
For those with suboptimal GC, daily divided dosing is recommended.
Magnesium should be offered concurrently to support vitamin D absorption and utilization.
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Seek out food sources of activated Vitamin D, often found in animal sources. 

For vegetarians or vegans consider supplementing with Vitamin D from algae-based or plant based sources if available.
Report: Diet and Nutrition
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Zinc Transport
Genes involved:
SLC30A8
RESULT + SUMMARY

This patient is more likely to have increased fasting and post-meal glucose levels. Glucose levels can be monitored with sufficient zinc supplementation.
SUPPLEMENT
RECOMMENDATIONS

Zinc
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Consume foods that will provide optimal levels of zinc, such as meat, shellfish, seafood, dairy, and eggs.
If you are vegan, consider eating more pumpkin seeds, legumes, nuts, and dark chocolate
Report: Diet and Nutrition
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Pesticides, Mold, and Toxins in Food
Genes involved:
GSTT1, GSTM1, GSTP1
RESULT + SUMMARY

This patient is more likely to respond negatively to an increased presence of pesticides, mold and other toxins in food.
Symptoms may include migraines or headaches after food consumption, hormone imbalances, stomach aches, bloating, and gut dysbiosis.
SUPPLEMENT
RECOMMENDATIONS

Youtrients Detox Optimizer
NAC
Milk Thistle
Selenium
Manganese
Alpha Lipoic Acid
Vitamin C
Magnesium
Sulforaphane
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Eat an array of fresh foods that have been minimally processed.
Reduce any exposure to chemicals and pesticides in non-organic foods.
Opt for mold and mycotoxin free coffee.
Report: Diet and Nutrition
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Dysregulated Hunger Patterns
Genes involved:
MC4R, FTO
RESULT + SUMMARY

This patient is more likely to have a dysregulated hunger response. They prefer to graze on snacks during the day, particularly at odd times. They may engage in "midnight snacking" or overeating. Interestingly enough, they are more likely to not feel hungry if they are engaged in a consuming task, sometimes for hours.
SUPPLEMENT
RECOMMENDATIONS

-
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Choose snacks that address different sensory aspects of the mouth, such as: sweet, salty, sour, fatty, crunchy, crispy, bitter, soft, and chewy. The more sensory profiles a snack can address, the more satisfied and less likely one will keep snacking or grazing.
Avoid snacking on soley carbs such as chips or crackers.
Choose protein and healthy fats as part the snack to reduce snacking frequency.
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Diet and Nutrition
GENE

GSTT1
CNV
(# of copies)
GENOTYPE + DESCRIPTION

2
Associated with increased enzyme function and clearance of substrates with increased ability to detoxify environmental xenobiotics, pharmaceutics and ROS
1
Associated with average enzyme function and clearance of substrates with average ability to detoxify environmental xenobiotics, pharmaceutics and ROS
0
Associated with no enzyme production and poorer clearance of substrates with decreased ability to detoxify environmental xenobiotics, pharmaceutics and ROS

GENE

GSTM1
CNV
(# of copies)
GENOTYPE + DESCRIPTION

2
Associated with increased enzyme function and clearance of substrates with increased ability to detoxify environmental xenobiotics, pharmaceutics and ROS
1
Associated with average enzyme function and clearance of substrates with average ability to detoxify environmental xenobiotics, pharmaceutics and ROS
0
Associated with no enzyme production and poorer clearance of substrates with decreased ability to detoxify environmental xenobiotics, pharmaceutics and ROS
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Diet and Nutrition
GENE

GSTP1
rs1695
GENOTYPE + DESCRIPTION

AA
Associated with optimal enzyme function and optimal clearance of substrates and reactive oxygen species
AG
Associated with sub-optimal enzyme function and suboptimal clearance of substrates and reactive oxygen species
GG
Associated with sub-optimal enzyme function and suboptimal clearance of substrates and reactive oxygen species

GENE

APOA2
rs5082
GENOTYPE + DESCRIPTION

AA
No association to weight gain in response to fat consumption
AG
Reduced association to weight gain in response to fat consumption
GG
Associated with weight gain and altered ghrelin production in response to saturated fat consumption
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Diet and Nutrition
GENE

TCF7L2
rs12255372
GENOTYPE + DESCRIPTION

GG
Associated with optimal insulin response and reduced risk of Type II diabetes
GT
Associated with suboptimal insulin response and increased risk of Type II diabetes
TT
Associated with suboptimal insulin response and increased risk of Type II diabetes

GENE

AMY1
rs4244372
GENOTYPE + DESCRIPTION

TT
Good starch metabolism. Reduced association between starch consumption and weight gain
AT
Moderate starch metabolism. Increased association between starch consumption and weight gain
AA
Poor starch metabolism. Increased association between starch consumption and weight gain
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Diet and Nutrition
GENE

SLC30A8
rs11558471
GENOTYPE + DESCRIPTION

AA
Associated with increased fasting glucose levels. Significantly associated with reduced fasting glucose levels in response to total zinc intake (a reduction in fasting glucose levels by 0.048 mmol/L (0.86mg/dL) with an average daily total zinc intake of 14mg)
AG
Associated with increased fasting glucose levels. Significantly associated with reduced fasting glucose levels in response to total zinc intake (a reduction in fasting glucose levels by 0.024 mmol/L (0.43mg/dL) with an average daily total zinc intake of 14mg)
GG
No independent association with increased fasting glucose levels. No significant association between total zinc intake and reduction in fasting glucose levels

GENE

BCMO1
rs11645428
GENOTYPE + DESCRIPTION

AA
Associated with optimal activation of beta-carotene into retinol
AG
Associated with moderate activation of beta-carotene into retinol
GG
Associated with suboptimal activation of beta-carotene into retinol
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Diet and Nutrition
GENE

SLC23A1
rs33972313
GENOTYPE + DESCRIPTION

GG
Associated with suboptimal catalytic activity (70 percent reduction) with increased susceptibility to oxidative stress within the mitochondria
AG
Associated with suboptimal levels of circulating vitamin C
AA
Associated with suboptimal levels of circulating vitamin C

GENE

CYP2R1
Rs10741657
GENOTYPE + DESCRIPTION

AA
Associated with optimal activation of vitamin D and optimal levels of circulating vitamin D
AG
Associated with suboptimal activation of vitamin D and suboptimal levels of circulating vitamin D
GG
Associated with suboptimal activation of vitamin D and suboptimal levels of circulating vitamin D
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Diet and Nutrition
GENE

GC/VDBP
Rs4588
GENOTYPE + DESCRIPTION

CC
Associated with optimal levels of vitamin D
AC
Associated with suboptimal levels of vitamin D
AA
Associated with suboptimal levels of vitamin D

GENE

VDR
rs1544410
GENOTYPE + DESCRIPTION

CC
Associated with optimal vitamin D receptor activation and binding
CT
Associated with suboptimal vitamin D receptor activation and binding
TT
Associated with suboptimal vitamin D receptor activation and binding
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Diet and Nutrition
GENE

MCM6
rs4988235
GENOTYPE + DESCRIPTION

AA
Associated with lactase persistence and lactose tolerance
AG
Associated with reduced lactase persistence and potential lactose intolerance (strongly dependent on post-weaning diet)
GG
Associated with lactase non-persistence and lactose intolerance

GENE

FTO
rs9939609
GENOTYPE + DESCRIPTION

TT
Associated with normal postprandial satiety with reduced risk of obesity in healthy individuals
AT
Associated with moderate postprandial satiety with moderate risk of obesity
AA
Associated with low postprandial satiety with increased risk of obesity
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Diet and Nutrition
GENE

MC4R
rs17782313
GENOTYPE + DESCRIPTION

TT
Associated with normative hunger cues and reduced snacking behaviour
CT
Associated with dysregulated hunger cues and increased snacking behaviour
CC
Associated with dysregulated hunger cues and increased snacking behaviour

GENE

UCP1
rs1800592
GENOTYPE + DESCRIPTION

AA
Associated with normal thermoregulatory control and resting metabolic rate with reduced resistance to weight loss
AG
Associated with suboptimal thermoregulatory control and resting metabolic rate with increased resistance to weight loss
GG
Associated with suboptimal thermoregulatory control and resting metabolic rate with increased resistance to weight loss