CONFIDENTIAL
CLINICIAN'S OVERVIEW
Cardiovascular
Report: Cardiovascular
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Chronic Inflammation
Genes involved:
9P21, 1P21, PCSK9
RESULT + SUMMARY

This patient carries an increased risk of chronic inflammation. From a cardiovascular perspective, this patient could potentially be at an increased risk of atherosclerosis and even an acute cardiac event such as a stroke or heart attack. Approach extensive and intensive periods of physical activity recommendations with increased care.
SUPPLEMENT
RECOMMENDATIONS

Youtrients - Omega 3 Fish Oil (Total Omega 2g)
Youtrients - Detox Optimizer
NAC
Milk Thistle
Selenium
Manganese
Alpha Lipoic Acid
Vitamin C
Magnesium
Sulforaphane
Youtrients - Methylation Optimizer
Vitamin B12 (methylated form if optimal MTR, adenosyl form if suboptimal MTR).
Vitamin B12 dosage based on further objective test results of levels in urine or serum.
Vitamin B9 (methylated form is optimal SHMT1, non-methylated forms such as folinic acid or folic acid if suboptimal SHMT1).
Vitamin B6
SAMe
Youtrients Mitochondrial Optimizer
Tocotrienols
Acetyl L-Carnitine
Ubiquinol
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Prioritize sleep. Help your patient understand why improving sleep is important to reducing inflammation.
Take and track relevant biomarkers of cardiovascular health: cholesterol panel, homocysteine, HbA1C, vitamin D, hs-CRP
Prioritize foods rich in B vitamins (fish, eggs, spinach, yeasts), anthocyanins (plums, cherries, red cabbage, eggplant), and reduce/avoid fried and sugary foods.
Report: Cardiovascular
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Hypercholesterolemia
Genes involved:
APOE, PCSK9
RESULT + SUMMARY

This patient carries an increased predisposition towards higher levels of cholesterol. Even with healthy lifestyle and dietary choices, it's still possible that they may present with higher than normal cholesterol levels.
SUPPLEMENT
RECOMMENDATIONS

Fiber (be it increased plants in diet or as a supplement)
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

If your triglycerides are below 90 mg/dl, we suggest you eat two tablespoons of oat bran each day for 12 weeks, two times a year.
If your triglycerides are above 90 mg/dl, we suggest you eat these foods on a daily basis:
8 almonds with skin dry roasted as a daily snack
200g of dark green leaves consumed throughout the day
Include 2 tbsp of a quality, raw extra-virgin olive oil into diet
Report: Cardiovascular
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Hypertension
Genes involved:
ACE, NOS3
RESULT + SUMMARY

This patient carries an increased risk of hypertension. Other than direct factors like ACE or NOS activity, cursory factors like anxiety and insulin resistance can also initiate periods of increased blood pressure readings.
SUPPLEMENT
RECOMMENDATIONS

Magnesium
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Encourage physical active every day and integration of physical activity into the day. Beyond fitness, think about adding movement throughout daily routine to get more time outside and increase baseline activity levels.
Find a mindfulness or meditation technique one enjoys and start practicing it for 5 minutes every morning.
Especially for those with suboptimal ACE, identify sodium sources and reduce all packaged, processed, and restaurant foods.
Reduce caffeine.
Report: Cardiovascular
Patient: Kashif Khan- New test kit
Patient ID: MG6644
HEALTH CONCERN

Poor Statin Response
Genes involved:
SLC01B1
RESULT + SUMMARY

This patient is more likely to have a suboptimal response to statins such as lipitor or crestor. Symptoms generally manifest as muscle pain as well as other forms of myalgia. Symptoms may not necessarily show up right away but can crop up a few weeks or months into the prescription regimen.
SUPPLEMENT
RECOMMENDATIONS

-
DIET, LIFESTYLE, AND ENVIRONMENT
RECOMMENDATIONS

Avoid statin drug use where possible
If required, consider other cholesterol management drugs first
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Cardiovascular
GENE

GSTT1
CNV
(# of copies)
GENOTYPE + DESCRIPTION

2
Associated with increased enzyme function and clearance of substrates with increased ability to detoxify environmental xenobiotics, pharmaceutics and ROS
1
Associated with average enzyme function and clearance of substrates with average ability to detoxify environmental xenobiotics, pharmaceutics and ROS
0
Associated with no enzyme production and poorer clearance of substrates with decreased ability to detoxify environmental xenobiotics, pharmaceutics and ROS

GENE

GSTM1
CNV
(# of copies)
GENOTYPE + DESCRIPTION

2
Associated with increased enzyme function and clearance of substrates with increased ability to detoxify environmental xenobiotics, pharmaceutics and ROS
1
Associated with average enzyme function and clearance of substrates with average ability to detoxify environmental xenobiotics, pharmaceutics and ROS
0
Associated with no enzyme production and poorer clearance of substrates with decreased ability to detoxify environmental xenobiotics, pharmaceutics and ROS
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Cardiovascular
GENE

GSTP1
rs1695
GENOTYPE + DESCRIPTION

AA
Associated with optimal enzyme function and optimal clearance of substrates and reactive oxygen species
AG
Associated with sub-optimal enzyme function and suboptimal clearance of substrates and reactive oxygen species
GG
Associated with sub-optimal enzyme function and suboptimal clearance of substrates and reactive oxygen species

GENE

SOD2
rs4880
GENOTYPE + DESCRIPTION

CC
Associated with optimal catalytic activity and optimal clearance of free radicals within the mitochondria
CT
Associated with 30 to 40 percent reduction in catalytic activity, with increased susceptibility to oxidative stress within the mitochondria
TT
Associated with suboptimal catalytic activity (70 percent reduction) with increased susceptibility to oxidative stress within the mitochondria
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Cardiovascular
GENE

GPX
rs1050450
GENOTYPE + DESCRIPTION

CC
Associated with faster conversion of hydrogen peroxide created from oxidant metabolism via SOD2 into water and diatomic oxygen
CT
Associated with medium conversion of hydrogen peroxide created from oxidant metabolism via SOD2 into water and diatomic oxygen
TT
Associated with slower conversion of hydrogen peroxide created from oxidant metabolism via SOD2 into water and diatomic oxygen

GENE

MTHFR
rs1801133
GENOTYPE + DESCRIPTION

CC
Associated with optimal enzyme function and 5-MTHF production
CT
Associated with moderate (30 to 35 percent reduction of) enzyme activity with intermediate 5-MTHF production
TT
Associated with suboptimal (~70 percent reduction of) enzymatic activity with low 5-MTHF production
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Cardiovascular
GENE

SHMT1
rs1979277
GENOTYPE + DESCRIPTION

GG
Associated with optimal bioavailability of cytosolic 5-MTHF and efficient homocysteine to methionine conversion (please note connectivity to MTHFR)
AG
Associated with reduced bioavailability of cytosolic 5-MTHF and efficient/moderately reduced homocysteine to methionine conversion
AA
Associated with suboptimal bioavailability of cytosolic 5-MTHF and efficient/moderately reduced homocysteine to methionine conversion with increased risk of cardiovascular disease when paired with MTHFR C/T and T/T (rs1801133)

GENE

MTR
rs1805087
GENOTYPE + DESCRIPTION

AA
Associated with optimal enzyme activity and conversion of homocysteine to methionine
AG
Associated with moderate enzyme activity with intermediate conversion of homocysteine to methionine
GG
Associated with suboptimal enzyme activity with suboptimal conversion of homocysteine to methionine (potentially resulting in elevated plasma homocysteine and DNA hypomethylation)
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Cardiovascular
GENE

MTRR
rs1801394
GENOTYPE + DESCRIPTION

AA
Associated with optimal enzyme activity and re-methylation of cobalamin to methylcobalamin (optimal bioavailability of methyl B12)
AG
Associated with reduced enzyme activity and moderate remethylation of cobalamin to methylcobalamin (potentially reduced bioavailability of methyl B12)
GG
Associated with suboptimal enzyme activity and suboptimal/poor re-methylation of cobalamin to methylcobalamin (potentially reduced bioavailability of methyl B12)

GENE

FUT2
rs601338
GENOTYPE + DESCRIPTION

AA
Associated with optimal enzyme function and plasma cobalamin levels
AG
Associated with moderate/possibly suboptimal enzyme function and plasma cobalamin levels
GG
Associated with low/suboptimal enzyme function and plasma cobalamin levels (particularly in the context of a vegetarian diet)
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Cardiovascular
GENE

9P21
rs10757278
rs10757274
rs4977574
GENOTYPE + DESCRIPTION

0-1G
Associated with lowest risk of coronary artery disease and ischemic stroke
2-3G
Associated with moderately increased risk of coronary artery disease and ischemic stroke
4-6G
Associated with increased risk of coronary artery disease and ischemic stroke

GENE

1P21
rs599839
GENOTYPE + DESCRIPTION

AA
Common genotype. Offers no additional protection against cardiovascular disease
AG
Rare Genotype. Carrying at least one G allele significantly reduces your risk of cardiovascular disease as well as levels of LDL cholesterol
GG
Rare Genotype. Carrying at least one G allele significantly reduces your risk of cardiovascular disease as well as levels of LDL cholesterol
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Cardiovascular
GENE

PCSK9
rs11591147
GENOTYPE + DESCRIPTION

GG
Common genotype. Offers no additional protection against cardiovascular disease
GT
Rare genotype. Offers significant protection against cardiovascular disease and is associated with lower triglyceride and LDL cholesterol levels
TT
Rare genotype. Offers significant protection against cardiovascular disease and is associated with lower triglyceride and LDL cholesterol levels

GENE

ACE**
Rs4343
GENOTYPE + DESCRIPTION

AA
Associated with low acting RAAS system, with low ACE plasma levels and activity
AG
Associated with moderate acting RAAS system, with moderate ACE plasma levels and activity
GG
Associated with highest acting RAAS system, with increased ACE plasma levels and activity
**Please note: Due to a phenomenon known as epistasis, results for the ACE and its associated outcomes differ based on population genetics. The results for east and south east asian individuals are exactly the opposite of those from caucasian or european backgrounds. For example, in an individual of European descent the A/A version would be considered the suboptimal result, it is actually the optimal version for those of East Asian or South East Asian descent.
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Cardiovascular
GENE

APOE
rs7412
rs429358
GENOTYPE + DESCRIPTION

2/2
Associated with increased risk of Type III hyperlipoproteinemia (HLP)
2/3
This genotype is associated with optimal lipid metabolism and optimal total and LDL-cholesterol levels
3/3
This genotype is the most common with no increased risk of coronary artery disease and ischemic stroke

GENE

GENOTYPE + DESCRIPTION

2/4
This genotype is very rare. However, of the few studies that have evaluated this genotype, it appears that the 2 allele mitigates any risk associated with the 4 allele. Therefore, this genotype is generally considered safe/protective.
3/4
Associated with moderately increased risk of coronary artery disease and ischemic stroke
4/4
Associated with increased risk of coronary artery disease and ischemic stroke
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Cardiovascular
GENE

NOS3
rs1799983
GENOTYPE + DESCRIPTION

GG
Optimal NOS response to vascular/blood flow-shear force with appropriate nitric oxide bioavailability
GT
Intermediate NOS response vascular/blood flow-shear force with moderate nitric oxide bioavailability
TT
Reduced NOS response to vascular/blood flow-shear force with decreased nitric oxide bioavailability

GENE

SLCO1B1
rs4149056
GENOTYPE + DESCRIPTION

TT
Normal statin metabolizer
CT
Decreased statin metabolizer. Increased risk of myopathy
CC
Significantly decreased statin metabolizer. Significantly increased risk of myopathy
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Cardiovascular
GENE

APOA2
rs5082
GENOTYPE + DESCRIPTION

AA
No association to weight gain in response to fat consumption
AG
Reduced association to weight gain in response to fat consumption
GG
Associated with weight gain and altered ghrelin production in response to saturated fat consumption

GENE

TCF7L2
rs12255372
GENOTYPE + DESCRIPTION

GG
Associated with optimal insulin response and reduced risk of Type II diabetes
GT
Associated with suboptimal insulin response and increased risk of Type II diabetes
TT
Associated with suboptimal insulin response and increased risk of Type II diabetes
Patient: Kashif Khan- New test kit
Patient ID: MG6644
Report: Cardiovascular
GENE

AMY1
rs4244372
GENOTYPE + DESCRIPTION

TT
Good starch metabolism. Reduced association between starch consumption and weight gain
AT
Moderate starch metabolism. Increased association between starch consumption and weight gain
AA
Poor starch metabolism. Increased association between starch consumption and weight gain

GENE

GENOTYPE + DESCRIPTION